Animal health innovation

The world’s first active immunization for chronic inflammatory conditions

Xeptiva devel­ops active immu­niza­tion against val­i­dated targets of chronic pain and inflam­ma­tion. A single plat­form, a partial and reversible response, and an effect that lasts for months.

2021founded on 10+ years of research
7programsthree species, one platform
200+dogs treatedacross our clinical studies
4patentapplications filed worldwide
Our mission

Improve com­pan­ion animals’ healthspan and life­span

Simple, afford­able and highly effec­tive immunother­a­pies for the chronic con­di­tions that affect com­pan­ion animals’ quality of life.

Learn more about us
The opportunity
500M+

pets live with chronic inflam­ma­tory con­di­tions, such as osteoarthri­tisatopic der­mati­tisobesitycancer

How they are treated today

NSAIDs

Daily oral anti-inflam­ma­to­ries. Widely used and effec­tive, but long-term use is limited by gas­troin­testi­nal and kidney tol­er­a­bil­ity.

Daily dosing

Monoclonal antibodies

Ready-made anti­bod­ies given by repeated injec­tions. Real-world use has brought reports of unwanted side effects, so treated animals need close mon­i­tor­ing.

Repeated injections

Steroids and JAK inhibitors

Fast control of itch and inflam­ma­tion. Long-term use calls for regular mon­i­tor­ing, and symp­toms tend to return when treat­ment stops.

Daily dosing
The platform

Where active immunization fits

Xeptiva’s immuno­gen trains the immune system to make its own anti­bod­ies, with a partial and reversible effect.

01

The animal’s own antibodies

The immune system is trained to produce its own anti­bod­ies against the medi­a­tors of chronic inflam­ma­tion.

02

Targets the root cause

Each immuno­gen neu­tral­izes a disease medi­a­tor together with Sub­stance P, the neu­ropep­tide that acti­vates mast cells and keeps neu­ro­genic inflam­ma­tion chronic.

03

Long-lasting effect

A short priming course keeps anti­body levels up for months, and a booster main­tains them.

04

Designed to be affordable

Made by recom­bi­nant fer­men­ta­tion, a simple and lower-cost process, and stored at 4 °C, so we can all benefit from inno­va­tive ther­a­pies.

How it works

  1. Immu­niza­tionWe give a mod­i­fied version of the target mol­e­cule, which the immune system rec­og­nizes.
  2. Own anti­bod­iesThe animal’s immune system makes its own anti­bod­ies against that target.
  3. Partial neu­tral­iza­tionThe anti­bod­ies reduce the target’s activ­ity without switch­ing it off com­pletely.
  4. Booster when neededAnti­body levels drop slowly over time, and a booster dose restores them.
  • 3 priming doses + booster
  • Recom­bi­nant pro­duc­tion
  • Stable at 4 °C
  • Reversible
Explore the platform →
Pipeline

One mechanism, seven programs

Program detail
Target identificationTarget
ID
Preclinical studiesPre-
clinical
Pilot & POC clinical studiesPilot &
POC
Clinical trialClinical
trial
RegistrationRegis-
tration
POC clinical trial
Target identification
Clinical data

Our clinical trials

Safety and effi­cacy trials in dogs and horses, com­pleted and ongoing, run in Uruguay and Chile together with aca­demic and clin­i­cal part­ners.

8clinical trials
4completed
4ongoing
See the clinical data →
Partnering

Let’s take active immunization further, together

Whether through acqui­si­tion, licens­ing or co-devel­op­ment, we are looking for part­ners who share our goal of bring­ing long-lasting solu­tions to com­pan­ion animals.

Acquisition

The company, the prod­ucts, the plat­form, the patents and the team, with full tech­nol­ogy trans­fer.

Licensing by territory

Rights to Xep01 or Xep02 in defined markets, with the devel­op­ment package and man­u­fac­tur­ing trans­fer.

Co-development

A new antigen for a new indi­ca­tion or species, run through the same pipe­line in Mon­te­v­ideo.

Talk to the team that ran the trials

Write to info@xeptiva.com or leave your details and we will answer within five busi­ness days.

Start a conversation
Supported by
Fen VenturesZentyneliThink VCND LatamUruguay Biotech VenturesSergio FogelScale Up by EndeavorPasaporte EmprendedorInstitut Pasteur de MontevideoANII
Awards and recognition