Pipeline / Xep03 · Cat · Osteoarthritis chronic pain

Chronic osteoarthritis pain in cats

A long-acting immunother­apy adapted to cats, tar­get­ing the neu­ro­genic inflam­ma­tion that keeps osteoarthri­tis pain going.

ProgramXep03
SpeciesCat
IndicationOsteoarthritis chronic pain
StagePreclinical studies
The disease

Why it matters

90%of cats over 12 years show radiographic signs of degenerative joint disease

Source: Hardie et al., JAVMA, 2002

Feline osteoarthri­tis is a pro­gres­sive, chronic joint disease that affects a sig­nif­i­cant share of adult cats, reduc­ing mobil­ity, joint func­tion and quality of life.

Cats tend to mask pain, which makes diag­no­sis dif­fi­cult. Less jumping, changes in groom­ing, social with­drawal or lower activ­ity are often the only signs of unman­aged chronic pain.

Target and mechanism

What the vaccine does

Feline OA pain stems not only from joint degen­er­a­tion but from per­sis­tent neu­ro­genic inflam­ma­tion. NGF and Sub­stance P sen­si­tize periph­eral nerve endings and drive central sen­si­ti­za­tion. Sub­stance P also acti­vates mast cells in the joint, which keeps the inflam­ma­tion chronic. By neu­tral­iz­ing both, Xeptiva’s tech­nol­ogy aims to disrupt this neu­roin­flam­ma­tory cascade.

How the platform works →
Evidence

Preclinical studies

  • This program is cur­rently in pre­clin­i­cal studies.
Partnering

Interested in this program?

Pro­to­cols, study reports and the reg­u­la­tory package are avail­able to qual­i­fied part­ners under con­fi­den­tial­ity.