OUR TECHNOLOGY
Recombinant multi-target immunogens based in Multiple Isomeric Epitopes targeting neurogenic inflammation.
1
Xeptiva's immunogens are multi-target fusion proteins exhibiting multiple conformational isomers of a single peptidic chain.
Immunogens lack the biological activity of targeted endogenous inflammatory mediators but share specific immunogenic structural epitopes.
2
Vaccination with Xeptiva's immunogens elicit antibodies in the host that recognize the targeted endogenous mediators involved in neurogenic inflammation, incluiding growth factors, interleukins and/or neuropeptides.
3
Vaccines generate neutralizing antibodies against two or more endogenous inflammatory mediators underlying chronic inflammation, pain, itching, tissue damage, etc.
4
Vaccination reduced chronic inflammation eliciting a long-term therapeutics effect on symptoms allowing tissue regeneration, improving quality of life.
Xeptiva's immunogens are multi-target fusion proteins exhibiting multiple conformational isomers of a single peptidic chain.
Immunogens lack the biological activity of targeted endogenous inflammatory mediators but share specific immunogenic structural epitopes.
2
Vaccination with Xeptiva's immunogens elicit antibodies in the host that recognize the targeted endogenous mediators involved in neurogenic inflammation, incluiding growth factors, interleukins and/or neuropeptides.
3
Vaccines generate neutralizing antibodies against two or more endogenous inflammatory mediators underlying chronic inflammation, pain, itching, tissue damage, etc.
4
Vaccination reduced chronic inflammation eliciting a long-term therapeutics effect on symptoms allowing tissue regeneration, improving quality of life.
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Pain in osteoarthritis
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Nociceptor sensitization in pain pathogenesis
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Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis
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IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis
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Molecular Mechanisms of Neurogenic Inflammation of
the Skin LM Jozefowicz, B Nedoszytko, M Grochocka, MA Zmijeweski, R Czajkowski, WJ Cubata & AT Slominski |
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Mast Cells and Sensory Nerves Contribute to Neurogenic Inflammation and Pruritus in Chronic Skin Inflammation
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Skin neurogenic inflammation JE Choi and A Di Nardo |
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