Xeptiva Therapeutics

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TECHNOLOGY

OUR TECHNOLOGY

Recombinant multi-target immunogens based in Multiple Isomeric Epitopes targeting neurogenic inflammation. 
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1
Xeptiva's immunogens are multi-target fusion proteins exhibiting multiple conformational isomers of a single peptidic chain.

Immunogens lack the biological activity of targeted endogenous inflammatory mediators but share specific immunogenic structural epitopes. 



2
Vaccination with Xeptiva's immunogens elicit antibodies in the host that recognize the targeted endogenous mediators involved in neurogenic inflammation, incluiding growth factors, interleukins and/or neuropeptides.


3
Vaccines generate neutralizing antibodies against two or more endogenous inflammatory mediators underlying chronic inflammation, pain, itching, tissue damage, etc.

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4
Vaccination reduced chronic inflammation eliciting a long-term therapeutics effect on symptoms allowing tissue regeneration, improving quality of life. 



RELATED publications

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September 2017
Pain in osteoarthritis
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L. Arendt-Nielsen​

read article
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May 2020
Contribution of nerves within osteochondral channels to osteoarthtritis knee pain in humans and rats

K Aso, S M Shahtaheri, R Hill, D Wilson, D F McWilliams, L N Nwoscu, V Chapman, D A Walsh
read article
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October 2009
Cellular and Molecular Mechanisms of Pain

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Al Basbaum, DM Bautista, G Sherrer, D Julius

read article
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October 2022
Osteoarthritis: New insight on its Pathophysiology


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S. Coaccioli, P Sarzi-Puttini, P Zis, G Rinonapoli and G Varrassi

READ ARTICLE
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March 2021
Neuroimmune interactions and osteoarthritis pain: focus on microphages



T Geraghty, D Winter, R Miller, R Miller, AM Malfait

read article
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January 2012
Neuroplasticity of sensory and sympathetic nerve fibers in a mouse model of a painful arthritic joint

​JR Ghiraldi, KT Freeman, JM Jimenez-Andrade, KA Coughlin, MJ Kaczmarska, G Castaneda-Corral, AP Bloom, MA Kuskowski, PW Mantyh
read article
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October 2010
Nociceptor sensitization in pain pathogenesis

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MS Gold & GF Gebhart
read article
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May 2021
Protective effect of sensory denervation in inflammatory arthtritis (evidence of regultarory neuroimmune pathways in the arthritic joint)

D Kane, J C Lockhart, PV Balint, C Mann, WR Ferrell, IB Mclannes
read article
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January 2023
The multifaceted role of mast cells in joint inflammation and arthritis


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A Loucks, T Maerz, K Hankenson, A Moeser & A Colbath
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read article
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February 2019
Substance P and Inflammatory Pain: Getting It Wrong and Right Simultaneously


​E Navratilova & F Porreca
read article
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​October 2022
Neurogenic inflammation as a novel treatment target for chronic pain syndromes

MF Seidel, T Hugle, B Morlion, M Koltzenburg, V Chapman, A MaassenVanDenBrink, NE. Lane, S Perrot, W Zieglgansberger
read article
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April 2020
​Risk Factors for Canine Osteoarthritis and Its Predisposing Arthropathies:
A Systematic Review


KL Anderson, H Zulch, DG O'neill, RL Meeson & LM Collins
read article
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April 2019
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Spontaneous dog osteoarthritis -
a One Medicine vision

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RL Meeson, RJ Todhunter, G Blunn, G Nuki & AA Pitsillides
read article
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November 2011
Identification of a central role for complement in osteoarthritis

Qi Wang, AL Rozelle, CM Lepus, CR Scanzello, JJ Song, DM Larsen, JF Crish, GBebek, SY Ritter, TM Lindstrom, I HWang, HH Wong, L Punzi, A Encarnacion, M Shamloo, SB Goodman, T Wyss-Coray, SR Goldring, NK Banda, JM Thurman, R Gobezie, MK Crow, VMI Holers, DM Lee & WH Robinson
read article
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August 2016
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Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis


​WH Robinson, CM Lepus, Q Wang, H Raghu, R Mao, TM Lindstrom & Jeremy Sokolove
read article
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May 2019
IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis

Q Wang, CM Lepus, H Raghu, LL Reber, MM Tsai, HH Wong, E von Kaeppler, N Lingampalli, MS Bloom, N Hu, EE Elliott, F Oliviero, L Punzi, NJ Giori, SB Goodman, CR Chu, J Sokolove, Y Fukuoka, LB Schwartz, SJ Galli, and WH Robinson 
read article
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March 2023
Molecular Mechanisms of Neurogenic Inflammation of
the Skin



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LM Jozefowicz, B Nedoszytko, M Grochocka, MA Zmijeweski, R Czajkowski, WJ Cubata & AT Slominski
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read article
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September 2019
Mast Cells and Sensory Nerves Contribute to Neurogenic Inflammation and Pruritus in Chronic Skin Inflammation



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H Siiskonen & I Harvima
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read article
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June 2022

Neuroimmune communication regulating pruritus in atopic dermatitis 


M Steinhoff, F Ahmad, A Pandey, A Datsi, A AlHammadi, S Al-Khawaga, A Al-Malki, J Meng, M Alam & J Buddenkotte
read article
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April 2018

​Skin neurogenic inflammation




​JE Choi and A Di Nardo
read article
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​February 2018

​Mast cell-neural interactions contribute to pain and itch



​K Gupta & IT Harvima
read article
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November 2016
The Role of Neurotrophins in Inflammation and Allergy

S Manti, P Brown, MK Perez & G Piedimonte
read article

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