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TECHNOLOGY
OUR TECHNOLOGY
Recombinant multi-target immunogens based in Multiple Isomeric Epitopes targeting neurogenic inflammation.
1
Multi-target fusion immunogens
Xeptiva's immunogens are multi-target fusion proteins exhibiting multiple conformational isomers of a single peptidic chain. Immunogens lack the biological activity of targeted endogenous inflammatory mediators but share specific immunogenic structural epitopes.
2
Targeting neurogenic inflammation
Vaccination with Xeptiva's immunogens elicit antibodies in the host that recognize the targeted endogenous mediators involved in neurogenic inflammation, including growth factors, interleukins and/or neuropeptides.
3
Neutralizing multiple mediators
Vaccines generate neutralizing antibodies against two or more endogenous inflammatory mediators underlying chronic inflammation, pain, itching, tissue damage, etc.
4
Long-term therapeutic effect
Vaccination reduced chronic inflammation eliciting a long-term therapeutic effect on symptoms allowing tissue regeneration, improving quality of life.
Production and characterization of rNGFSP: a recombinant fusion immunogen eliciting dual anti-NGF and anti-Substance P therapeutic antibodies for Degenerative Joint Disease
V Varela, M Costa, C Maciel , J Barbeito, E Barrera, E Gutierre, A Correa, M Elgue , S Carrasco, M Domínguez Larrosa, M Pereira, J Correa, N Crosignani, J Beckman, L Barbeito, E Trias
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